Teratogenic risks of antiepileptic drugs.
نویسندگان
چکیده
منابع مشابه
Teratogenic effects of antiepileptic drugs
The use of older generation antiepileptic drugs (AEDs) during pregnancy is known to be associated with a two- to threefold increased risk of birth defects in the offspring and possible also other adverse outcomes in the exposed infant. Much less has been known about newer generation AEDs in this respect. Recent studies based on national registries as well as specific epilepsy and pregnancy regi...
متن کاملNeurological teratogenic effects of antiepileptic drugs during pregnancy
Epilepsy is one of the few neurologic disorders that requires a constant treatment during pregnancy. Epilepsy affects 0.3-0.8% of pregnant women. Prescription of antiepileptic drugs (AEDs) to pregnant women with epilepsy requires monitoring and maintaining a balance between limiting seizures and decreasing fetal exposure to the potential teratogenic effects. AEDs are also commonly used for psyc...
متن کاملTeratogenic Potential of Antiepileptic Drugs in the Zebrafish Model
The zebrafish model is an attractive candidate for screening of developmental toxicity during early drug development. Antiepileptic drugs (AEDs) arouse concern for the risk of teratogenicity, but the data are limited. In this study, we evaluated the teratogenic potential of seven AEDs (carbamazepine (CBZ), ethosuximide (ETX), valproic acid (VPN), lamotrigine (LMT), lacosamide (LCM), levetiracet...
متن کاملTeratogenic effects of antiepileptic medications.
Data on clinical teratogenicity are at best derived from carefully conducted observational studies, whereas randomized, controlled trials have no place in this research area. We can only expect level B recommendations and lower. New relevant information has become available during the last 5 years on pregnancy outcomes with 3 of the most frequently used AEDs: carbamazepine, valproate, and lamot...
متن کاملBrand spanking? The presumptive risks of generic antiepileptic drugs.
Commentary In a room full of epilepsy physicians—or their patients—the one topic most likely to cause the proverbial excrement to strike the rotating blades is that of generic antiepileptic drugs (AEDs). Passions run high, with those at one end of the worry spectrum convinced that the widespread use of generics poses a primordial threat to the well-being of patients with seizures, while those a...
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ژورنال
عنوان ژورنال: BMJ
سال: 1981
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.283.6303.1405-d